HACE1 prevents lung carcinogenesis via inhibition of RAC-family GTPases

HACE1 is an E3 ubiquitin ligase with important roles in tumor biology and tissue homeostasis. Loss or mutation of HACE1 has been associated with the occurrence of a variety of neoplasms, but the underlying mechanisms have not been defined yet. Here we report that HACE1 is frequently mutated in human...

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Publicado en:Cancer Res
Main Authors: Kogler, Melanie, Tortola, Luigi, Negri, Gian Luca, Leopoldi, Alexandra, El-Naggar, Amal M., Mereiter, Stefan, Diaz, Carlos Gomez, Nitsch, Roberto, Tortora, Davide, Kavirayani, Anoop M., Gapp, Bianca V., Rao, Shuan, Uribesalgo, Iris, Hoffmann, David, Cikes, Domagoj, Novatchkova, Maria, Williams, David A., Trent, Jeffrey M., Ikeda, Fumiyo, Daugaard, Mads, Hagelkruys, Astrid, Sorensen, Poul H., Penninger, Josef M.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611202/
https://ncbi.nlm.nih.gov/pubmed/32366477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-2270
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