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IAPs as E3 ligases of Rac1: Shaping the move

Inhibitors of Apoptosis Proteins (IAPs) are well-studied E3 ubiquitin ligases predominantly known for regulation of apoptosis. We uncovered that IAPs can function as a direct E3 ubiquitin ligase of RhoGTPase Rac1. cIAP1 and XIAP directly conjugate polyubiquitin chains to Lysine 147 of activated Rac1...

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Detalhes bibliográficos
Main Authors: Oberoi-Khanuja, Tripat Kaur, Rajalingam, Krishnaraj
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408978/
https://ncbi.nlm.nih.gov/pubmed/22790203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.19988
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