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Loss of the E3 ubiquitin ligase HACE1 results in enhanced Rac1 signaling contributing to breast cancer progression

The transition from ductal carcinoma in situ (DCIS) to invasive breast cancer (IBC) is a crucial step in breast cancer progression. The specific alterations that govern this transition have not been elucidated. HER2/neu is frequently overexpressed in DCIS but is less common in IBC, thereby suggestin...

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Vydáno v:Oncogene
Hlavní autoři: Goka, E T, Lippman, M E
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633721/
https://ncbi.nlm.nih.gov/pubmed/25659579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.468
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