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The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway

The Hippo kinase pathway is emerging as a conserved signaling pathway that is essential for organ growth and tumorigenesis. Recently, we reported that the ubiquitin E3 ligase ITCH negatively regulates LATS1, thereby increasing YAP activity, which leads to increased cell proliferation and decreased a...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Salah, Zaidoun, Itzhaki, Ella, Aqeilan, Rami I
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279417/
https://ncbi.nlm.nih.gov/pubmed/25350971
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