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Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability
The large tumor suppressor 1 (LATS1) is a serine/threonine kinase and tumor suppressor found down-regulated in a broad spectrum of human cancers. LATS1 is a central player of the emerging Hippo-LATS suppressor pathway, which plays important roles in cell proliferation, apoptosis, and stem cell diffe...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3064387/ https://ncbi.nlm.nih.gov/pubmed/21383157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101273108 |
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