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Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability

The large tumor suppressor 1 (LATS1) is a serine/threonine kinase and tumor suppressor found down-regulated in a broad spectrum of human cancers. LATS1 is a central player of the emerging Hippo-LATS suppressor pathway, which plays important roles in cell proliferation, apoptosis, and stem cell diffe...

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Bibliographic Details
Main Authors: Ho, King Ching, Zhou, Zhonghua, She, Yi-Min, Chun, Alex, Cyr, Terry D., Yang, Xiaolong
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064387/
https://ncbi.nlm.nih.gov/pubmed/21383157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101273108
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