Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex

BRCA1 is a breast and ovarian cancer tumor suppressor protein that associates with BARD1 to form a RING/RING heterodimer. The BRCA1/BARD1 RING complex functions as an ubiquitin (Ub) ligase with activity substantially greater than individual BRCA1 or BARD1 subunits. By using NMR spectroscopy and site...

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Detalhes bibliográficos
Main Authors: Brzovic, Peter S., Keeffe, Jennifer R., Nishikawa, Hiroyuki, Miyamoto, Keiko, Fox, David, Fukuda, Mamoru, Ohta, Tomohiko, Klevit, Rachel
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC156255/
https://ncbi.nlm.nih.gov/pubmed/12732733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0836054100
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