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Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms
The tumor‐suppressor protein BRCA1 works with BARD1 to catalyze the transfer of ubiquitin onto protein substrates. The N‐terminal regions of BRCA1 and BARD1 that contain their RING domains are responsible for dimerization and ubiquitin ligase activity. This activity is a common feature among hundred...
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| Publicado no: | Protein Sci |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5326557/ https://ncbi.nlm.nih.gov/pubmed/27977889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3091 |
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