Human BRCA1-BARD1 Ubiquitin ligase activity counters chromatin barriers to DNA resection

The opposing activities of 53BP1 and BRCA1 influence pathway choice of DNA double-strand break repair. How BRCA1 counters the inhibitory effect of 53BP1 on DNA resection and homologous recombination is unknown. Here we identify the site of BRCA1-BARD1 required for priming ubiquitin transfer from E2~...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Densham, Ruth M, Garvin, Alexander J., Stone, Helen R., Strachan, Joanna, Baldock, Robert A, Daza-Martin, Manuel, Fletcher, Alice, Blair-Reid, Sarah, Beesley, James, Johal, Balraj, Pearl, Laurence H., Neely, Robert, Keep, Nicholas H., Watts, Felicity Z, Morris, Joanna R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522385/
https://ncbi.nlm.nih.gov/pubmed/27239795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3236
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados