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The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair

The protein product of the breast and ovarian cancer gene, BRCA1, is part of an obligate heterodimer with BARD1. Together these RING bearing proteins act as an E3 ubiquitin ligase. Several functions have been attributed to BRCA1 that contribute to genome integrity but which of these, if any, require...

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Publicado en:Nucleus
Autores principales: Densham, Ruth M., Morris, Joanna R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5403137/
https://ncbi.nlm.nih.gov/pubmed/28032817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2016.1267092
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