Human BRCA1-BARD1 Ubiquitin ligase activity counters chromatin barriers to DNA resection

The opposing activities of 53BP1 and BRCA1 influence pathway choice of DNA double-strand break repair. How BRCA1 counters the inhibitory effect of 53BP1 on DNA resection and homologous recombination is unknown. Here we identify the site of BRCA1-BARD1 required for priming ubiquitin transfer from E2~...

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Udgivet i:Nat Struct Mol Biol
Main Authors: Densham, Ruth M, Garvin, Alexander J., Stone, Helen R., Strachan, Joanna, Baldock, Robert A, Daza-Martin, Manuel, Fletcher, Alice, Blair-Reid, Sarah, Beesley, James, Johal, Balraj, Pearl, Laurence H., Neely, Robert, Keep, Nicholas H., Watts, Felicity Z, Morris, Joanna R.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522385/
https://ncbi.nlm.nih.gov/pubmed/27239795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3236
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