BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1

Mutations in BRCA1/BARD1’s E3 ubiquitin ligase RING domains predispose carriers to breast and ovarian cancers. We present the first structure of the BRCA1/BARD1 RING heterodimer with the E2 enzyme UbcH5c bound to its cellular target, the nucleosome, along with biochemical data that explain how the c...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Witus, Samuel R., Burrell, Anika L., Farrell, Daniel P., Kang, Jianming, Wang, Meiling, Hansen, Jesse M., Pravat, Alex, Tuttle, Lisa M., Stewart, Mikaela D., Brzovic, Peter S., Chatterjee, Champak, Zhao, Weixing, DiMaio, Frank, Kollman, Justin M., Klevit, Rachel E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8007219/
https://ncbi.nlm.nih.gov/pubmed/33589814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-00556-4
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