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Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome
The Polycomb group of epigenetic enzymes represses expression of developmentally regulated genes in higher eukaryotes. This group includes the Polycomb repressive complex 1 (PRC1), which ubiquitylates nucleosomal histone H2A Lys119 using its E3 ubiquitin ligase subunits, Ring1B and Bmi1, together wi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4215650/ https://ncbi.nlm.nih.gov/pubmed/25355358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13890 |
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