BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1

Mutations in BRCA1/BARD1’s E3 ubiquitin ligase RING domains predispose carriers to breast and ovarian cancers. We present the first structure of the BRCA1/BARD1 RING heterodimer with the E2 enzyme UbcH5c bound to its cellular target, the nucleosome, along with biochemical data that explain how the c...

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Bibliografski detalji
Izdano u:Nat Struct Mol Biol
Glavni autori: Witus, Samuel R., Burrell, Anika L., Farrell, Daniel P., Kang, Jianming, Wang, Meiling, Hansen, Jesse M., Pravat, Alex, Tuttle, Lisa M., Stewart, Mikaela D., Brzovic, Peter S., Chatterjee, Champak, Zhao, Weixing, DiMaio, Frank, Kollman, Justin M., Klevit, Rachel E.
Format: Artigo
Jezik:Inglês
Izdano: 2021
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8007219/
https://ncbi.nlm.nih.gov/pubmed/33589814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-00556-4
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