BARD1 is necessary for ubiquitylation of nucleosomal histone H2A and for transcriptional regulation of estrogen metabolism genes

Missense mutations that disrupt the RING domain of the tumor suppressor gene BRCA1 lead to increased risk of breast and ovarian cancer. The BRCA1 RING domain is a ubiquitin ligase, whose structure and function rely critically on forming a heterodimer with BARD1, which also harbors a RING domain. The...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Stewart, Mikaela D., Zelin, Elena, Dhall, Abhinav, Walsh, Tom, Upadhyay, Esha, Corn, Jacob E., Chatterjee, Champak, King, Mary-Claire, Klevit, Rachel E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819413/
https://ncbi.nlm.nih.gov/pubmed/29367421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715467115
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