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Nucleosome binding by the lysine specific demethylase 1 (LSD1) enzyme enables histone H3 demethylation
The essential human enzyme lysine specific demethylase 1 (LSD1) silences genes by demethylating mono- and dimethylated lysine 4 in histone H3 (H3K4me1/2). Studies of the minimal requirements for LSD1 activity are complicated by the heterogeneity of histone modification states in cells. We overcame t...
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| 出版年: | Biochemistry |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7640899/ https://ncbi.nlm.nih.gov/pubmed/32567837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00412 |
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