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Chemically sumoylated histone H4 stimulates intranucleosomal demethylation by the LSD1-CoREST complex
Lysine-specific demethylase 1 (LSD1) downregulates eukaryotic gene activity by demethylating mono and dimethylated Lys4 in histone H3. Elucidating the biochemical crosstalk of LSD1 with histone post-translational modifications (PTMs) is essential for developing LSD1-targeted therapeutics in human ca...
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| Publicado no: | ACS Chem Biol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5726507/ https://ncbi.nlm.nih.gov/pubmed/28832116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00716 |
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