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Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms
The tumor‐suppressor protein BRCA1 works with BARD1 to catalyze the transfer of ubiquitin onto protein substrates. The N‐terminal regions of BRCA1 and BARD1 that contain their RING domains are responsible for dimerization and ubiquitin ligase activity. This activity is a common feature among hundred...
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| 出版年: | Protein Sci |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5326557/ https://ncbi.nlm.nih.gov/pubmed/27977889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3091 |
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