Interaction of BARD1 and HP1 is required for BRCA1 retention at sites of DNA damage

Stable retention of BRCA1/BARD1 complexes at sites of DNA damage is required for the proper response to DNA double-strand breaks (DSB). Here, we demonstrate that the BRCT domain of BARD1 is crucial for its retention through interaction with HP1. In response to DNA damage, BARD1 interacts with Lys9-d...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Wu, Wenwen, Nishikawa, Hiroyuki, Fukuda, Takayo, Vittal, Vinayak, Asano, Masahide, Miyoshi, Yasuo, Klevit, Rachel E., Ohta, Tomohiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003120/
https://ncbi.nlm.nih.gov/pubmed/25634209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2796
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