Structural mechanism for the regulation of HCN ion channels by the accessory protein TRIP8b

Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels underlie the cationic I(h) current present in many neurons. The direct binding of cAMP to HCN channels increases the rate and extent of channel opening and results in a depolarizing shift in the voltage dependence of activation....

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Bibliographic Details
Published in:Structure
Main Authors: DeBerg, Hannah A., Bankston, John R., Rosenbaum, Joel C., Brzovic, Peter S., Zagotta, William N., Stoll, Stefan
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394039/
https://ncbi.nlm.nih.gov/pubmed/25800552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.02.007
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