A bifunctional role for the UHRF1 UBL domain in the control of hemi-methylated DNA-dependent histone ubiquitylation

DNA methylation patterns regulate gene expression programs and are maintained through a highly coordinated process orchestrated by the RING E3 ubiquitin ligase UHRF1. UHRF1 controls DNA methylation inheritance by reading epigenetic modifications to histones and DNA to activate histone H3 ubiquitylat...

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Détails bibliographiques
Publié dans:Mol Cell
Auteurs principaux: DaRosa, Paul A., Harrison, Joseph S., Zelter, Alex, Davis, Trisha N., Brzovic, Peter, Kuhlman, Brian, Klevit, Rachel E
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239910/
https://ncbi.nlm.nih.gov/pubmed/30392931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.09.029
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