Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance

UHRF1 is a histone- and DNA-binding E3 ubiquitin ligase that functions with DNMT1 to maintain mammalian DNA methylation. UHRF1 facilitates DNMT1 recruitment to replicating chromatin through a coordinated mechanism involving histone and DNA recognition and histone ubiquitination. UHRF2 shares structu...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphovsmän: Vaughan, Robert M, Dickson, Bradley M, Cornett, Evan M, Harrison, Joseph S, Kuhlman, Brian, Rothbart, Scott B
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2018
Ämnen:
Gene regulation, Chromatin and Epigenetics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961305/
https://ncbi.nlm.nih.gov/pubmed/29506131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky151
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