SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1

Faithful inheritance of DNA methylation across cell division requires DNMT1 and its accessory factor UHRF1. However, how this axis is regulated to ensure DNA methylation homeostasis remains poorly understood. Here we show that SET8, a cell-cycle-regulated protein methyltransferase, controls protein...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Zhang, Huifang, Gao, Qinqin, Tan, Shuo, You, Jia, Lyu, Cong, Zhang, Yunpeng, Han, Mengmeng, Chen, Zhaosu, Li, Jialun, Wang, Hailin, Liao, Lujian, Qin, Jun, Li, Jiwen, Wong, Jiemin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753495/
https://ncbi.nlm.nih.gov/pubmed/31400111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz626
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