SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1

Faithful inheritance of DNA methylation across cell division requires DNMT1 and its accessory factor UHRF1. However, how this axis is regulated to ensure DNA methylation homeostasis remains poorly understood. Here we show that SET8, a cell-cycle-regulated protein methyltransferase, controls protein...

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Detaylı Bibliyografya
Yayımlandı:Nucleic Acids Res
Asıl Yazarlar: Zhang, Huifang, Gao, Qinqin, Tan, Shuo, You, Jia, Lyu, Cong, Zhang, Yunpeng, Han, Mengmeng, Chen, Zhaosu, Li, Jialun, Wang, Hailin, Liao, Lujian, Qin, Jun, Li, Jiwen, Wong, Jiemin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2019
Konular:
Gene regulation, Chromatin and Epigenetics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753495/
https://ncbi.nlm.nih.gov/pubmed/31400111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz626
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