Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1

The epigenetic inheritance of DNA methylation requires UHRF1, a histone- and DNA-binding RING E3 ubiquitin ligase that recruits DNMT1 to sites of newly replicated DNA through ubiquitylation of histone H3. UHRF1 binds DNA with selectivity towards hemi-methylated CpGs (HeDNA); however, the contributio...

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Bibliographic Details
Published in:eLife
Main Authors: Harrison, Joseph S, Cornett, Evan M, Goldfarb, Dennis, DaRosa, Paul A, Li, Zimeng M, Yan, Feng, Dickson, Bradley M, Guo, Angela H, Cantu, Daniel V, Kaustov, Lilia, Brown, Peter J, Arrowsmith, Cheryl H, Erie, Dorothy A, Major, Michael B, Klevit, Rachel E, Krajewski, Krzysztof, Kuhlman, Brian, Strahl, Brian D, Rothbart, Scott B
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2016
Subjects:
Biochemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012860/
https://ncbi.nlm.nih.gov/pubmed/27595565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17101
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