Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition

UHRF1 is an important epigenetic regulator for maintenance DNA methylation. UHRF1 recognizes hemi-methylated DNA (hm-DNA) and trimethylation of histone H3K9 (H3K9me3), but the regulatory mechanism remains unknown. Here we show that UHRF1 adopts a closed conformation, in which a C-terminal region (Sp...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Fang, Jian, Cheng, Jingdong, Wang, Jiaolong, Zhang, Qiao, Liu, Mengjie, Gong, Rui, Wang, Ping, Zhang, Xiaodan, Feng, Yangyang, Lan, Wenxian, Gong, Zhou, Tang, Chun, Wong, Jiemin, Yang, Huirong, Cao, Chunyang, Xu, Yanhui
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822050/
https://ncbi.nlm.nih.gov/pubmed/27045799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11197
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires