Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition

UHRF1 is an important epigenetic regulator for maintenance DNA methylation. UHRF1 recognizes hemi-methylated DNA (hm-DNA) and trimethylation of histone H3K9 (H3K9me3), but the regulatory mechanism remains unknown. Here we show that UHRF1 adopts a closed conformation, in which a C-terminal region (Sp...

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發表在:Nat Commun
Main Authors: Fang, Jian, Cheng, Jingdong, Wang, Jiaolong, Zhang, Qiao, Liu, Mengjie, Gong, Rui, Wang, Ping, Zhang, Xiaodan, Feng, Yangyang, Lan, Wenxian, Gong, Zhou, Tang, Chun, Wong, Jiemin, Yang, Huirong, Cao, Chunyang, Xu, Yanhui
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822050/
https://ncbi.nlm.nih.gov/pubmed/27045799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11197
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