Conformational dynamics of the TTD–PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability

UHRF1 is a key mediator of inheritance of epigenetic DNA methylation patterns during cell division and is a putative target for cancer therapy. Recent studies indicate that interdomain interactions critically influence UHRF1's chromatin-binding properties, including allosteric regulation of its...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Houliston, R. Scott, Lemak, Alexander, Iqbal, Aman, Ivanochko, Danton, Duan, Shili, Kaustov, Lilia, Ong, Michelle S., Fan, Lixin, Senisterra, Guillermo, Brown, Peter J., Wang, Yun-Xing, Arrowsmith, Cheryl H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743070/
https://ncbi.nlm.nih.gov/pubmed/29074623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.799700
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