Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: INSIGHTS INTO NUCLEOTIDE SPECIFICITY, DIMERIZATION, AND cGMP-DEPENDENT CONFORMATIONAL CHANGE

Phosphodiesterase 5 (PDE5) controls intracellular levels of cGMP through its regulation of cGMP hydrolysis. Hydrolytic activity of the C-terminal catalytic domain is increased by cGMP binding to the N-terminal GAF A domain. We present the NMR solution structure of the cGMP-bound PDE5A GAF A domain....

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Detalhes bibliográficos
Main Authors: Heikaus, Clemens C., Stout, Joseph R., Sekharan, Monica R., Eakin, Catherine M., Rajagopal, Ponni, Brzovic, Peter S., Beavo, Joseph A., Klevit, Rachel E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504876/
https://ncbi.nlm.nih.gov/pubmed/18534985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801577200
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