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The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding
Cyclic nucleotide phosphodiesterases (PDEs) regulate all pathways that use cGMP or cAMP as a second messenger. Five of the 11 PDE families have regulatory segments containing GAF domains, 3 of which are known to bind cGMP. In PDE2 binding of cGMP to the GAF domain causes an activation of the catalyt...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC130621/ https://ncbi.nlm.nih.gov/pubmed/12271124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192374899 |
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