The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding

Cyclic nucleotide phosphodiesterases (PDEs) regulate all pathways that use cGMP or cAMP as a second messenger. Five of the 11 PDE families have regulatory segments containing GAF domains, 3 of which are known to bind cGMP. In PDE2 binding of cGMP to the GAF domain causes an activation of the catalyt...

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Bibliographic Details
Main Authors: Martinez, Sergio E., Wu, Albert Y., Glavas, Natalie A., Tang, Xiao-Bo, Turley, Stewart, Hol, Wim G. J., Beavo, Joseph A.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC130621/
https://ncbi.nlm.nih.gov/pubmed/12271124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.192374899
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