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The Structure of the GAF A Domain from Phosphodiesterase 6C Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-dependent Conformational Change

The photoreceptor phosphodiesterase (PDE6) regulates the intracellular levels of the second messenger cGMP in the outer segments of cone and rod photoreceptor cells. PDE6 contains two regulatory GAF domains, of which one (GAF A) binds cGMP and regulates the activity of the PDE6 holoenzyme. To increa...

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Autors principals: Martinez, Sergio E., Heikaus, Clemens C., Klevit, Rachel E., Beavo, Joseph A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533791/
https://ncbi.nlm.nih.gov/pubmed/18614542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802891200
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