Structural Analysis of the Regulatory GAF Domains of cGMP Phosphodiesterase Elucidates the Allosteric Communication Pathway

Regulation of photoreceptor phosphodiesterase (PDE6) activity is responsible for the speed, sensitivity, and recovery of the photoresponse during visual signaling in vertebrate photoreceptor cells. It is hypothesized that physiological differences in the light responsiveness of rods and cones may re...

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Udgivet i:J Mol Biol
Main Authors: Gupta, Richa, Liu, Yong, Wang, Huanchen, Nordyke, Christopher T., Puterbaugh, Ryan Z., Cui, Wenjun, Varga, Krisztina, Chu, Feixia, Ke, Hengming, Vashisth, Harish, Cote, Rick H.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572642/
https://ncbi.nlm.nih.gov/pubmed/32898583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.08.026
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