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Allosteric regulation of rod photoreceptor phosphodiesterase 6 (PDE6) elucidated by chemical cross-linking and quantitative mass spectrometry
Photoreceptor phosphodiesterase (PDE6) is the central effector enzyme in the visual excitation pathway in rod and cone photoreceptors. Its tight regulation is essential for the speed, sensitivity, recovery and adaptation of visual signaling. The rod PDE6 holoenzyme (Pαβγ(2)) is composed of a catalyt...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6733632/ https://ncbi.nlm.nih.gov/pubmed/31394113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.07.035 |
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