The molecular architecture of photoreceptor phosphodiesterase 6 (PDE6) with activated G protein elucidates the mechanism of visual excitation

Photoreceptor phosphodiesterase 6 (PDE6) is the central effector of the visual excitation pathway in both rod and cone photoreceptors, and PDE6 mutations that alter PDE6 structure or regulation can result in several human retinal diseases. The rod PDE6 holoenzyme consists of two catalytic subunits (...

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Vydáno v:J Biol Chem
Hlavní autoři: Irwin, Michael J., Gupta, Richa, Gao, Xiong-Zhuo, Cahill, Karyn B., Chu, Feixia, Cote, Rick H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926442/
https://ncbi.nlm.nih.gov/pubmed/31690623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011002
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