Identification of Amino Acid Residues Responsible for the Selectivity of Tadalafil Binding to Two Closely Related Phosphodiesterases, PDE5 and PDE6

The 11 families of the Class I cyclic nucleotide phosphodiesterases (PDEs) are critical for regulation of cyclic nucleotide signaling. PDE5 (important in regulating vascular smooth muscle contraction) and PDE6 (responsible for regulating visual transduction in vertebrate photoreceptors) are structur...

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Bibliografske podrobnosti
Main Authors: Cahill, Karyn B., Quade, Jonathan H., Carleton, Karen L., Cote, Rick H.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510839/
https://ncbi.nlm.nih.gov/pubmed/23033484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.389189
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