Identification of Amino Acid Residues Responsible for the Selectivity of Tadalafil Binding to Two Closely Related Phosphodiesterases, PDE5 and PDE6

The 11 families of the Class I cyclic nucleotide phosphodiesterases (PDEs) are critical for regulation of cyclic nucleotide signaling. PDE5 (important in regulating vascular smooth muscle contraction) and PDE6 (responsible for regulating visual transduction in vertebrate photoreceptors) are structur...

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Hlavní autoři: Cahill, Karyn B., Quade, Jonathan H., Carleton, Karen L., Cote, Rick H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510839/
https://ncbi.nlm.nih.gov/pubmed/23033484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.389189
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