The N termini of the inhibitory γ-subunits of phosphodiesterase-6 (PDE6) from rod and cone photoreceptors differentially regulate transducin-mediated PDE6 activation

Phosphodiesterase-6 (PDE6) plays a central role in both rod and cone phototransduction pathways. In the dark, PDE6 activity is suppressed by its inhibitory γ-subunit (Pγ). Rhodopsin-catalyzed activation of the G protein transducin relieves this inhibition and enhances PDE6 catalysis. We hypothesized...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Wang, Xin, Plachetzki, David C., Cote, Rick H.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544851/
https://ncbi.nlm.nih.gov/pubmed/30962282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007520
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