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Structural Requirements of the Photoreceptor Phosphodiesterase γ-Subunit for Inhibition of Rod PDE6 Holoenzyme and for Its Activation by Transducin

The central enzyme of the visual transduction cascade, cGMP phosphodiesterase (PDE6), is regulated by its γ-subunit (Pγ), whose inhibitory constraint is released upon binding of activated transducin. It is generally believed that the last four or five C-terminal amino acid residues of Pγ are respons...

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Bibliografiske detaljer
Main Authors: Zhang, Xiu-Jun, Skiba, Nikolai P., Cote, Rick H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836051/
https://ncbi.nlm.nih.gov/pubmed/19948718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.057406
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