Efficacy and selectivity of phosphodiesterase-targeted drugs to inhibit photoreceptor phosphodiesterase (PDE6) in retinal photoreceptors

PURPOSE: Phosphodiesterase (PDE) inhibitors are important therapeutic agents, but their effects on photoreceptor PDE (PDE6) and photoreceptor cells are poorly understood. We characterized the potency and selectivity of various classes of PDE inhibitors on purified rod and cone PDE6 and on intact rod...

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Bibliographic Details
Main Authors: Zhang, Xiujun, Feng, Qing, Cote, Rick H.
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1343468/
https://ncbi.nlm.nih.gov/pubmed/16123402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.05-0257
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