Three Mitochondrial DNA Polymerases Are Essential for Kinetoplast DNA Replication and Survival of Bloodstream Form Trypanosoma brucei

Por Bruhn, David F., Sammartino, Mark P., Klingbeil, Michele M.
Publicado em 2011

Activation of Exogenous Fatty Acids to Acyl-Acyl Carrier Protein Cannot Bypass FabI Inhibition in Neisseria

Por Yao, Jiangwei, Bruhn, David F., Frank, Matthew W., Lee, Richard E., Rock, Charles O.
Publicado no J Biol Chem (2016)

Synthesis and antibacterial evaluation of macrocyclic diarylheptanoid derivatives

Por Lin, Hao, Bruhn, David F., Maddox, Marcus M., Singh, Aman P., Lee, Richard E., Sun, Dianqing
Publicado no Bioorg Med Chem Lett (2016)

Design, Synthesis and Microbiological Evaluation of Ampicillin Tetramic acid Hybrid Antibiotics

Por Cherian, Philip T., Deshpande, Aditi, Cheramie, Martin N., Bruhn, David F., Hurdle, Julian G., Lee, Richard E.
Publicado no J Antibiot (Tokyo) (2016)

Silencing of a putative inner arm dynein heavy chain results in flagellar immotility in Trypanosoma brucei

Por Springer, Amy L., Bruhn, David F., Kinzel, Kathryn W., Rosenthal, Noël F., Zukas, Randi, Klingbeil, Michele M.
Publicado em 2010

Synthesis and evaluation of Pretomanid (PA-824) oxazolidinone hybrids

Por Rakesh, Bruhn, David F., Scherman, Michael S., Singh, Aman P., Yang, Lei, Liu, Jiuyu, Lenaerts, Anne J., Lee, Richard E.
Publicado no Bioorg Med Chem Lett (2015)

In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics

Por Bruhn, David F., Scherman, Michael S., Liu, Jiuyu, Scherbakov, Dimitri, Meibohm, Bernd, Böttger, Erik C., Lenaerts, Anne J., Lee, Richard E.
Publicado no Sci Rep (2015)

Patients with Type 2 Diabetes Initiating Exenatide Twice Daily or Insulin in Clinical Practice: CHOICE Study

Por Matthaei, Stephan, Reaney, Matthew, Mathieu, Chantal, Östenson, Claes-Göran, Krarup, Thure, Guerci, Bruno, Kiljanski, Jacek, Petto, Helmut, Bruhn, David, Theodorakis, Michael
Publicado em 2012

Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes

Por Bruhn, David F., Wyllie, Susan, Rodríguez-Cortés, Adaris, Carrillo, Angela K., Rakesh, Guy, R. Kiplin, Fairlamb, Alan H., Lee, Richard E.
Publicado no J Antimicrob Chemother (2016)

Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents

Por Shen, Li, Maddox, Marcus, Adhikari, Sudip, Bruhn, David F., Kumar, Manish, Lee, Robin E., Hurdle, Julian G., Lee, Richard E., Sun, Dianqing
Publicado em 2013

Treatment outcomes after initiation of exenatide twice daily or insulin in clinical practice: 12-month results from CHOICE in six European countries

Por Östenson, Claes-Göran, Matthaei, Stephan, Reaney, Matthew, Krarup, Thure, Guerci, Bruno, Kiljanski, Jacek, Salaun-Martin, Carole, Sapin, Hélène, Bruhn, David, Mathieu, Chantal, Theodorakis, Michael
Publicado em 2013

Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models

Por Robertson, Gregory T., Scherman, Michael S., Bruhn, David F., Liu, Jiuyu, Hastings, Courtney, McNeil, Michael R., Butler, Michelle M., Bowlin, Terry L., Lee, Robin B., Lee, Richard E., Lenaerts, Anne J.
Publicado no J Antimicrob Chemother (2017)

Design, Synthesis and Anti-tuberculosis Activity of 1-Adamantyl-3-heteroaryl Ureas with Improved in vitro Pharmacokinetic Properties

Por North, E. Jeffrey, Scherman, Michael S., Bruhn, David F., Scarborough, Jerrod S., Maddox, Marcus M., Jones, Victoria, Grzegorzewicz, Anna, Yang, Lei, Hess, Tamara, Morisseau, Christophe, Jackson, Mary, McNeil, Michael R., Lee, Richard E.
Publicado em 2013

Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties

Por Rakesh, Bruhn, David, Madhura, Dora B., Maddox, Marcus, Lee, Robin B., Trivedi, Ashit, Yang, Lei, Scherman, Michael S., Gilliland, Janet C., Gruppo, Veronica, McNeil, Michael R., Lenaerts, Anne J., Meibohm, Bernd, Lee, Richard E.
Publicado em 2012

Pentacyclic Nitrofurans with In Vivo Efficacy and Activity against Nonreplicating Mycobacterium tuberculosis

Por Rakesh, Bruhn, David F., Scherman, Michael S., Woolhiser, Lisa K., Madhura, Dora B., Maddox, Marcus M., Singh, Aman P., Lee, Robin B., Hurdle, Julian G., McNeil, Michael R., Lenaerts, Anne J., Meibohm, Bernd, Lee, Richard E.
Publicado em 2014

Synthesis, Structure–Activity Relationship Studies, and Antibacterial Evaluation of 4-Chromanones and Chalcones, as Well as Olympicin A and Derivatives

Por Feng, Li, Maddox, Marcus M., Alam, Md. Zahidul, Tsutsumi, Lissa S., Narula, Gagandeep, Bruhn, David F., Wu, Xiaoqian, Sandhaus, Shayna, Lee, Robin B., Simmons, Charles J., Tse-Dinh, Yuk-Ching, Hurdle, Julian G., Lee, Richard E., Sun, Dianqing
Publicado em 2014

Aminomethyl Spectinomycins as Novel Therapeutics for Drug Resistant Respiratory Tract and Sexually Transmitted Bacterial Infections

Por Bruhn, David F., Waidyarachchi, Samanthi L., Madhura, Dora B., Shcherbakov, Dimitri, Zheng, Zhong, Liu, Jiuyu, Abdelrahman, Yasser M., Singh, Aman P., Duscha, Stefan, Rathi, Chetan, Lee, Robin B., Belland, Robert J., Meibohm, Bernd, Rosch, Jason W., Böttger, Erik C., Lee, Richard E.
Publicado no Sci Transl Med (2015)

The Structure-Activity Relationships of Spectinamide Antituberculosis agents; a Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions

Por Liu, Jiuyu, Bruhn, David F., Lee, Robin. B., Zheng, Zhong, Janusic, Tanja, Scherbakov, Dimitri, Scherman, Michael S., Boshoff, Helena I., Das, Sourav, Rakesh, Waidyarachchi, Samanthi L., Brewer, Tiffany A., Gracia, Begoña, Yang, Lei, Bollinger, John, Robertson, Gregory T., Meibohm, Bernd, Lenaerts, Anne J., Ainsa, Jose, Böttger, Erik C., Lee, Richard E.
Publicado no ACS Infect Dis (2016)

Spectinamides: A New Class of Semisynthetic Anti-Tuberculosis Agents that Overcome Native Drug Efflux

Por Lee, Richard E., Hurdle, Julian G., Liu, Jiuyu, Bruhn, David F., Matt, Tanja, Scherman, Michael S., Vaddady, Pavan K, Zheng, Zhong, Qi, Jianjun, Akbergenov, Rashid, Das, Sourav, Madhura, Dora B., Rathi, Chetan, Trivedi, Ashit, Villellas, Cristina, Lee, Robin. B., Rakesh, Waidyarachchi, Samanthi L., Sun, Dianqing, McNeil, Michael R., Ainsa, Jose A., Boshoff, Helena I., Gonzalez-Juarrero, Mercedes, Meibohm, Bernd, Böttger, Erik C., Lenaerts, Anne J.
Publicado em 2014