Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties

A series of tetracyclic nitrofuran isoxazoline antituberculosis agents was designed and synthesized to improve the pharmacokinetic properties of an initial lead compound, which had potent antituberculosis activity but suffered from poor solubility, high protein binding and rapid metabolism. In this...

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Huvudupphovsmän: Rakesh, Bruhn, David, Madhura, Dora B., Maddox, Marcus, Lee, Robin B., Trivedi, Ashit, Yang, Lei, Scherman, Michael S., Gilliland, Janet C., Gruppo, Veronica, McNeil, Michael R., Lenaerts, Anne J., Meibohm, Bernd, Lee, Richard E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582038/
https://ncbi.nlm.nih.gov/pubmed/22995771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.08.023
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