Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties

A series of tetracyclic nitrofuran isoxazoline antituberculosis agents was designed and synthesized to improve the pharmacokinetic properties of an initial lead compound, which had potent antituberculosis activity but suffered from poor solubility, high protein binding and rapid metabolism. In this...

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Bibliografski detalji
Glavni autori: Rakesh, Bruhn, David, Madhura, Dora B., Maddox, Marcus, Lee, Robin B., Trivedi, Ashit, Yang, Lei, Scherman, Michael S., Gilliland, Janet C., Gruppo, Veronica, McNeil, Michael R., Lenaerts, Anne J., Meibohm, Bernd, Lee, Richard E.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582038/
https://ncbi.nlm.nih.gov/pubmed/22995771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.08.023
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