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Phase II Metabolic Pathways of Spectinamide Antitubercular Agents: A Comparative Study of the Reactivity of 4-Substituted Pyridines to Glutathione Conjugation

Spectinamides are promising new semisynthetic anti-tubercular agents that are modified with a pyridyl side chain, which blocks native efflux from the tuberculosis cell. This study, describes the stability of an advanced panel of spectinamide analogs, with varying substitutions to the pyridyl side ch...

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Pubblicato in:Medchemcomm
Autori principali: Madhura, Dora B., Liu, Juiyu, Meibohm, Bernd, Lee, Richard E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4814158/
https://ncbi.nlm.nih.gov/pubmed/27042286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C5MD00349K
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