Spectinamides: A New Class of Semisynthetic Anti-Tuberculosis Agents that Overcome Native Drug Efflux

Although the classical antibiotic spectinomycin is a potent bacterial protein synthesis inhibitor, poor antimycobacterial activity limits its clinical application for treating tuberculosis. Using structure-based design, a novel semisynthetic series of spectinomycin analogs was generated with selecti...

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Detalhes bibliográficos
Main Authors: Lee, Richard E., Hurdle, Julian G., Liu, Jiuyu, Bruhn, David F., Matt, Tanja, Scherman, Michael S., Vaddady, Pavan K, Zheng, Zhong, Qi, Jianjun, Akbergenov, Rashid, Das, Sourav, Madhura, Dora B., Rathi, Chetan, Trivedi, Ashit, Villellas, Cristina, Lee, Robin. B., Rakesh, Waidyarachchi, Samanthi L., Sun, Dianqing, McNeil, Michael R., Ainsa, Jose A., Boshoff, Helena I., Gonzalez-Juarrero, Mercedes, Meibohm, Bernd, Böttger, Erik C., Lenaerts, Anne J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972818/
https://ncbi.nlm.nih.gov/pubmed/24464186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3458
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