Comparative Pharmacokinetics of Spectinamide 1599 after Subcutaneous and Intrapulmonary Aerosol Administration in Mice

Spectinamides are a novel series of spectinomycin analogs being developed for the treatment of tuberculosis. Intrapulmonary aerosol (IPA) administration of lead spectinamide 1599 has previously been shown to be more efficacious than subcutaneous (SC) administration at comparable doses. The objective...

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Udgivet i:Tuberculosis (Edinb)
Main Authors: Rathi, Chetan, Lukka, Pradeep B., Wagh, Santosh, Lee, Richard E., Lenaerts, Anne J., Braunstein, Miriam, Hickey, Anthony, Gonzalez-Juarrero, Mercedes, Meibohm, Bernd
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362843/
https://ncbi.nlm.nih.gov/pubmed/30711150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tube.2018.12.006
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