The Structure-Activity Relationships of Spectinamide Antituberculosis agents; a Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions

Spectinamides are a novel class of antitubercular agents with the potential to treat drug resistant tuberculosis infections. Their antitubercular activity is derived from both ribosomal affinity and their ability to overcome intrinsic efflux mediated by the Mycobacterium tuberculosis Rv1258c efflux...

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Publicado no:ACS Infect Dis
Main Authors: Liu, Jiuyu, Bruhn, David F., Lee, Robin. B., Zheng, Zhong, Janusic, Tanja, Scherbakov, Dimitri, Scherman, Michael S., Boshoff, Helena I., Das, Sourav, Rakesh, Waidyarachchi, Samanthi L., Brewer, Tiffany A., Gracia, Begoña, Yang, Lei, Bollinger, John, Robertson, Gregory T., Meibohm, Bernd, Lenaerts, Anne J., Ainsa, Jose, Böttger, Erik C., Lee, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5493200/
https://ncbi.nlm.nih.gov/pubmed/28081607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00158
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