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Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents

The natural product engelhardione is an underexplored chemotype for developing novel treatments for bacterial infections; we therefore explored this natural product scaffold for chemical diversification and structure-activity relationship studies. Macrocyclic engelhardione and structural regioisomer...

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Autori principali: Shen, Li, Maddox, Marcus, Adhikari, Sudip, Bruhn, David F., Kumar, Manish, Lee, Robin E., Hurdle, Julian G., Lee, Richard E., Sun, Dianqing
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696040/
https://ncbi.nlm.nih.gov/pubmed/23549356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ja.2013.21
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