Pharmacophore Modeling, Synthesis, and Antibacterial Evaluation of Chalcones and Derivatives

[Image: see text] A series of novel chalcone and thiol-Michael addition analogues was synthesized and tested against Mycobacterium tuberculosis and other clinically significant bacterial pathogens. Previously reported chalcone-like antibacterials (1a–c and 2) were used as a training set to generate...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Zhang, Mingming, Prior, Allan M., Maddox, Marcus M., Shen, Wan-Jou, Hevener, Kirk E., Bruhn, David F., Lee, Robin B., Singh, Aman P., Reinicke, Justin, Simmons, Charles J., Hurdle, Julian G., Lee, Richard E., Sun, Dianqing
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6312637/
https://ncbi.nlm.nih.gov/pubmed/30613820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b03174
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