Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes

OBJECTIVES: In response to reports of Trypanosoma brucei resistance to the nitroaromatic drug nifurtimox, we evaluated the potential of antituberculosis nitrofuran isoxazolines as inhibitors of trypanosome growth. METHODS: The susceptibility of T. brucei brucei was assessed in vitro. The lowest effe...

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Bibliografiske detaljer
Udgivet i:J Antimicrob Chemother
Main Authors: Bruhn, David F., Wyllie, Susan, Rodríguez-Cortés, Adaris, Carrillo, Angela K., Rakesh, Guy, R. Kiplin, Fairlamb, Alan H., Lee, Richard E.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4790617/
https://ncbi.nlm.nih.gov/pubmed/26682963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv417
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