Chemical and genetic validation of dihydrofolate reductase–thymidylate synthase as a drug target in African trypanosomes

The phenotypes of single- (SKO) and double-knockout (DKO) lines of dihydrofolate reductase–thymidylate synthase (DHFR–TS) of bloodstream Trypanosoma brucei were evaluated in vitro and in vivo. Growth of SKO in vitro is identical to wild-type (WT) cells, whereas DKO has an absolute requirement for th...

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Библиографические подробности
Главные авторы: Sienkiewicz, Natasha, Jarosławski, Szymon, Wyllie, Susan, Fairlamb, Alan H
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Publishing Ltd 2008
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610392/
https://ncbi.nlm.nih.gov/pubmed/18557814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2008.06305.x
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