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Substrate channeling between the human dihydrofolate reductase and thymidylate synthase

In vivo, as an advanced catalytic strategy, transient non‐covalently bound multi‐enzyme complexes can be formed to facilitate the relay of substrates, i. e. substrate channeling, between sequential enzymatic reactions and to enhance the throughput of multi‐step enzymatic pathways. The human thymidyl...

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Bibliographische Detailangaben
Veröffentlicht in:Protein Sci
Hauptverfasser: Wang, Nuo, McCammon, J. Andrew
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815301/
https://ncbi.nlm.nih.gov/pubmed/26096018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2720
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