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Substrate channeling between the human dihydrofolate reductase and thymidylate synthase

In vivo, as an advanced catalytic strategy, transient non‐covalently bound multi‐enzyme complexes can be formed to facilitate the relay of substrates, i. e. substrate channeling, between sequential enzymatic reactions and to enhance the throughput of multi‐step enzymatic pathways. The human thymidyl...

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Bibliografiske detaljer
Udgivet i:Protein Sci
Main Authors: Wang, Nuo, McCammon, J. Andrew
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4815301/
https://ncbi.nlm.nih.gov/pubmed/26096018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2720
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