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Substrate channeling between the human dihydrofolate reductase and thymidylate synthase
In vivo, as an advanced catalytic strategy, transient non‐covalently bound multi‐enzyme complexes can be formed to facilitate the relay of substrates, i. e. substrate channeling, between sequential enzymatic reactions and to enhance the throughput of multi‐step enzymatic pathways. The human thymidyl...
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| Veröffentlicht in: | Protein Sci |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4815301/ https://ncbi.nlm.nih.gov/pubmed/26096018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2720 |
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