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First Three-Dimensional Structure of Toxoplasma gondii thymidylate synthase-dihydrofolate reductase: Insights for Catalysis, Interdomain Interactions, and Substrate Channeling
Most species, such as humans, have monofunctional forms of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) that are key folate metabolism enzymes making critical folate components required for DNA synthesis. In contrast, several parasitic protozoa, including Toxoplasma gondii, contain a...
Tallennettuna:
| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2013
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3905773/ https://ncbi.nlm.nih.gov/pubmed/24053355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400576t |
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